By Murilo Bomfim
In the jungle of a biodiversity, scientist seeks compounds that give fit with illnesses
Regardless of where you live, it is quite possible that there is at least one pharmacy near a your home. Brazil has 2 countries with the most drugstores in the world: according to the IQVIA consultancy, we have one for every 2.200 inhabitants. In Argentina, some pharmacy serves 3. people; in India, 2 million.
Zero however, on the champion of everyday drugstores beyond, u Brazil highlights zero question pharmacies perform the future: from an immense unknown electronic biodiversity on its bacterium molecules can be extracted to the formulation of new drugs. However, unlike the establishment of a corner, biodiversity does not have a password or a desk attendant panning for molecules present in any biome, a more complex task.
Daniela Trivella some scientists who immerse themselves in nature above about compounds with pharmacological activity. In her daily life, she hunts for molecules in samples collected in places as different as the Amazon or the perform scar fund, for example, where some decomposing whale carcass with potential compounds was found at a depth of about 4,000 meters.
Graduated in biology, the researcher has a master’s degree in biotechnology, a doctorate in biomolecular physics and electronic post-docs in chemistry and electronic pharmacology. Such a diversified academic trajectory made it possible to develop techniques aimed at the interaction of electronic proteins and bioactive compounds, with windows looking at new medicines. It is common for proteins to be involved in disease mechanisms; some antidepressants, for example, act on proteins to increase concentrations and perform noradrenaline hormone. For an active compound to interact with some protein, there needs to be a go with, a fit between them. Electronic this fitting depends on perform electronic format 2 atoms present in the compound: this conformation that can stimulate or inhibit protein activity.
Trivella coordinates some team perform National Laboratory on Biosciences (LNBio), in Campinas , where thus sent samples of electronic plants bacteria collected by specialized partners that I learned venture into the most different corners perform pas one that guarantees the diversity in the library about natural products that u LNBio has been putting together, currently with 6 million registered samples. The issue is that each sample contains several bioactive compounds, with only a few being relevant for inspiring new drugs. How, then, to identify the specific compound that interacts with a particular protein?
Researchers ze use two techniques. Some protein crystallography, which works like some fishing: the protein (in crystal form) is the bait, electronic is the sample to be tested the scar. When the sony ericsson sample compound binds protein, both form a complex that is later analyzed by Sirius, the particle accelerator inaugurated in Campinas in 2018. At the end of the perform process, there is the three-dimensional structure of the protein with the connected compound.
The strategy is complemented by mass spectrometry, which provides what would be the printout electronic perform compound, electronic the From which it is possible to know operating system atoms that form the bioactive molecule. Armed with these information obtained by both techniques, the team crosses electronic data and identifies the molecule in question, which can give rise to the long-awaited medications.
These crosses, however, lead to pace electronics. subject to electronic errors frustrations the molecule may be known or even irrelevant to the production of a drug. To speed up the process, Trivella has now learned to build a computer user interface that takes care of these intersections. like ze it was Tinder 2 medicines: therefore information inserted electronically the program points out who matches with whom electronic which couples will be more fruitful.
To develop the idea, the team, composed about chemicals, pharmacists electronic biologists, it also has an electronic computer scientist and a mathematician. This diversity of knowledge is essential to unite Brazilian high-tech electronic biodiversity. Sony ericsson everything works out, new drugs will hit the market. Pharmacies will not be missing.
Murilo Bomfim journalist.
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