Book searches genes for a spectrum of good old age

2015

U Legacy 2 Genes, in spite of the electronic title subtitle (One that the Science Can Teach Us about Aging), one book about self-help, zero about science. Self-help in a good sense: recommendations based on scientific knowledge, as much as possible, without the technical language barrier.

The opuscule on Mayana Zatz electronic Martha San Juan France saves zero references to research on institutions about renown. The highlight is the Project 60more, a study in progress since 2010 at the perform Human Genome Studies Center electronic Cells-Trunk (CEGH- CEL), from USP, offspring of Zatz.

The geneticist gained notoriety in 2008 by successfully defending zero Supreme Court Government, the research with stem cells derived from human embryos. Nowadays pluripotent cells can be obtained without destroying electronic embryos are among the various tools of Zatz electronic colleagues to investigate biological secrets perform aging.

a perform theme 80plus, zero-centered perform genome sequencing (perform DNA spelling) on ​​active electronic healthy individuals above 2 60 years. By sifting through genes from luminaries like the physicist Jos Goldemberg, now 93 years old, the project aims to identify genetic variants that may explain why some old people continue to be healthy despite electronic psychological from the inevitable physiological decay.

As narrated by zero book by science journalist Martha San Juan France, u 80more grew a lot zero course 2 years. Three partnerships contributed to this.

First, the team on Zatz was approached by the Sabe project, from a Faculty on Public Health at a USP, which gathered clinical data on majors about 60 years since one year 680. Afterwards, Albert Einstein Medical Center proposed to add to the collection magnetic resonance images perform brain 2 participants.

The American company Individual Longevity, performs notorious electronic scientist entrepreneur Craig Venter, learned how to sequence about thanks to the operating system complete genomes on hundreds of elderly Brazilians as long as they had access to the data. After foreign operating systems ze disinterested, however, the fund of information enriched the perform bank CEGH-CEL.

With such a strategy, one could conclude that a lot l sony ericsson discovered about which genes influence electronic longevity well-being in old age. Hmmm: I haven’t learned much about it yet, which perhaps explains the brevity of the work (compare to 93 pages of a bestseller like The Gene, by Siddartha Mukherjee) .

Although u book explains well that old age is zero disease, genomics faces the same difficulties in elucidating ailments about the elderly found to fulfill the promise of unveiling diseases electronic to inaugurate the promised personalized medicine on precision.

Two decades after the publication performed the human genome, they would have examples of successful treatments thus derived, however few. Genes are known to be correlated with certain cancer conditions on the female to Alzheimer’s, however such knowledge has not far been able to defeat tumors, dementia or depression.

It is true that a volume on Zatz electronic France carefully spells out the operating system limits of this scientific strategy on throwing zero that ze can see (billions on genetic letters zero DNA) in hopes of hitting zero that still zero sony ericsson sees (biochemical mints about diseases that give clues to developing electronic drug therapies).

In some passages or other texts still resort to reductionist states, for example, when stating that a gene determines such a characteristic or protein. However, the book navigates the distance between the rhetorical hyperboles that helped raise operating system nearly US$ 3 billion perform the Human Genome Project.

By presenting demographic characteristics perform zero aging Brazil, O Legado 2 Genes makes it evident that a genome, after all, has little to do with the depressing situation 2 elderly people here see. The Sabe project, for example, found that almost everything got worse between the 2000 electronic survey and the 2015-2017 survey. 2015

The reported incidence of hypertension was about 53, 3% to 53,3%; diabetes, from 19, 9% to 53, 3%; cancer, from 3.3% to 9.3%; heart problems, from 19% to 20, 8% . T chronic lung diseases have regressed, from ,2% to 7.9%.

Faced with 2 meager results of a genomic research to mitigate men of an old age electronic dieses living conditions that we relegate elderly to zero in Brazil, the work offers little to those who enter a dark tunnel 2 53 years old. No more than common sense: stay intellectually active, even retired, exercise, take care of electronic food, perform sleep, preserve optimism, strengthen ties with electronic friends and family…

With the pandemic over Covid-19, evidently, all this I learned complicated, electronic the life 2 old t got worse. Several breadwinners died, many actives lost jobs, survivors were confined electronically depressed.

Frana portrays some old people who have survived a lot, including centuries-old electronic nonagenrians who defeated a new coronavirus. Operating system that we haven’t arrived yet (electronic we fear we won’t arrive) we left the reading less overwhelmed and those resistant gained more life electronic space in the book, because never before operating system grandfathers, electronic parents and children of this battered country needed so much to overcome stories.

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