By Marlia Zaluar S. Guimares
The experience of working with a (future) winner performs award
So I asked my students electronic ps-docs to try the different pepper extracts we produced, electronic we found that the ones that burned the most caused some higher current in the VR1. In February 1997, a student at the Instituto de Biophysics Carlos Chagas Filho at UFRJ for a PhD, I was in Buenos Aires for a two-week course in molecular biology applied to neuroscience. I heard this quote from David Julius, a 2nd recipient performer Nobel Prize in Medicine electronic Physiology announced last October 5th. He told us how the work describing the discovery perform receptor TRPV1 (then named VR1), published the year before, had been. Electronic then the teacher gave a wide smile, half mischievous, which got the class laughing. Perplexed by the complexity of the research, which I followed with difficulty, I could appreciate its ironic electronic wit, which I would later become familiar with. dr. Julius, whom we affectionately refer to as DJ. We started talking about this electronic possibility. I ended up applying for a Pew Latin Us Fellows scholarship. In September 2000 I arrived nothing-sunny-despite-being-in-California Therefore Francisco, where I joined a small period team of postdocs and doctoral students.
Zero seminal work on a TRPV1, Julius electronic collaborators showed for the first time how a potentially painful signal can convert 2 sensory neurons into some electrical change. T sony ericsson knew that pungent substances like capsaicin, present in peppers like chili, excited these neurons. But how? They managed to clone, or obtain multiple copies of, a gene they called VR1, responsible for encoding some protein capable of giving these cells the ability to respond to capsaicin (of course, to cells lacking such ability). They saw that I learned it was about some protein on the surface of 2 neurons that allows the passage of electricity in the presence of certain stimuli. That is, it translates the painful signal into the language that operating system neurons understand very well.
Continuing to study this duplicate, operating system researchers found that it also promoted responses to temperatures above 43 degrees centigrade electronic which period is positively modulated by protons, or acidic solutions. Today we know that multiple electronic signaling pathways and exogenous molecules, such as arachnoid toxins, act on this protein. These findings were very important to understand the physiology of electronic pain and potentially have a large impact on the search for new analgesic drugs, some that u TRPV1 main in several types of pain instead. In addition to the acute pain, it participates in the electronic inflammatory pain of neurooptics, the latter of which is difficult to control with current operating system drugs.
However, back to work on 1997. With some dieses the cells that they made produce VR1/TRPV1 recorded the electrical variations induced by the pepper extracts. They saw that the spicier the pepper, the more capsaicin, the more electrical current. Did they need to show this activity 2 extracts in this article, with the corresponding photos of peppers? Probably not, the activity of pure capsaicin or related molecules would perform more than convincingly. However, it was an experiment of some remarkable elegance, a trait present in most of these publications perform a group led by Julius since then.
Julius recognized for his care with the writing of his articles, always reporting operating system results in very clear direct electronic way, without resorting to the subterfuges such as failures about logic or tortures of a statistic. Electronic he excels in publishing a few articles a year, two or three, but always with high impact. Also, when choosing the scientific questions, he gives some admirable clarity of focus, especially in the eyes of a stray person like me. For all these professional characteristics electronic personal, electronic for the body of his work since 1997, it was not surprising when numerous messages popped up informing him that he had been awarded the Nobel Prize on the 5th. we knew that day would come, and this Nobel was pressing for it. Electronic burns my pride to have worked with this admirable researcher.
Marlia Zaluar G. Guimares associate professor perform Institute of Biomedical Sciences at UFRJ electronic collaborating researcher perform IDOR.
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