A control of a malaria can be zero menu on a protozoan

By Fabio Gomes

How do you Plasmodium assemble an army specializing in the transmission of a disease


For decades, an issue has been intriguing operating system malaria researchers: like a


, u protozoan that causes a disease, coordinates its electronic multiplication assembles an army on highly specialized cells in the infection 2 mosquitoes that transmit it? Research on this phenomenon may be the key to combating this evil that kills more than thousand people a year on the planet.

The main Symptoms of a disease begin days after a mosquito performs a bite, when a Plasmodium infects electronic breaks our red blood cells, like blood cells responsible for transporting over gases. In fact, what induces typical malaria fever is this cell disruption, which occurs in replication cycles of the periodic fever of the infected person. During this long cycle, while most 2 ze parasites multiply into cells that will infect new new red blood cells, other sony ericsson differentiate into gametocytes, a specialized invader performer in the infection of mosquitoes. Operating system mechanisms of this process no therefore are well understood, however some studies suggest that the appetite of these organisms is part of the equation.

Like other parasites, u Plasmodium uses operating system nutrients perform body perform its host. The red blood cells they infect are replete with hemoglobin, a protein I learned binds t molecules on electronic oxygen and transports them around our body. The hemoglobin present in the infected cell is an important food source for him, but it does not provide a complete menu. Thus, it takes other foods outside an infected cell, including other sources of amino acids, lipids and electronic sugars.

Glucose, a primary sugar used as a source of energy, one of these captured nutrients , electronic by all indications is the main part of a coordination of an invader perform multiplication. In a survey of infected monkeys, researchers found that a low-sugar (low calorie) diet led to a reduction in the proliferation rates Plasmodium. However, other nutrients also participate in coordinating the life cycle of this protozoon. In a recent study, Harvard electronic scientists at the University of Glasgow have pointed to the role of lysophosphatidylcholine during gametocyte production. Important component of electronic membranes that perform our blood, this lipid also acts in the regulation of our immune response. As malaria progresses, there is a reduction in electronic lysophosphatidylcholine 2 levels of other therefore consumed lipids as the infection progresses. The usurper detects this electronic reduction, when lysophosphatidylcholine reaches a very low level, forms capable of infecting operating system mosquitoes appear.

Apparently, a parasite identifies when it has already removed many features perform electronic host needs to migrate to a new one. However, there are still many pieces to this puzzle. For example, there appear to be differences in the dynamics of gametocyte formation between different species of Plasmodium. There is also a sophisticated genetic coordination of this process, electronic operating system scientists still do not fully understand how the appetite of these species coordinates this mechanics. On the other hand, these clues encourage further studies to refine this understanding.

The administration of drugs capable of acting electronically killing operating system gametocytes is essential for the control of malaria. However, the main drugs available today can cause the destruction of red blood cells in people with deficiency of the enzyme G6PD, a disease that affects about millions of people worldwide. The need to carefully perform these drugs, including the implementation of tests to screen for this deficiency, ends up limiting the administration of performing medication. Unveiling operating system mechanisms associated with the development of electronic infection and the formation of gametocytes can be an essential step to identify new drugs that can block this electronic process the infection of new mosquitoes.


Fabio Gomes professor perform Institute on Biophysics Carlos Chagas Filho of a UFRJ electronic member perform Laboratory on Cellular Ultrastructure Hertha Meyer.

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