The Ruleville Police Department, Drew Police Department, Sunflower County Sheriff's Department and even a couple of state troopers responded to the school.
Principal Darron Edwards said he doesn't believe the conflicts were related to this year's merging of Drew Hunter High School with Central.
This is the first year the long time rival border towns are attending high school under the same roof.
"Based on the preliminary evidence we have at this point, it appears the fights did not involve Ruleville kids versus Drew kids," Edwards said.
Edwards said he could not release many details as the incidents are under further investigation by the school,and they will be receiving assistance from Ruleville Police if needed.
"Our number one priority is safety," added Edwards. "There are going to be fights at school and sometimes they unfold beyond control. Our trained and certified staff did a good job of diffusing more fights from occurring."
Edwards could not confirm how many students took part in the melee but all who involved were sent home.
Ruleville Police Captain Amos Mitchner said he believes there were about 10 students sent home and they are likely to be suspended.
"The teachers and students did everything they could to get the children under control," he added. "Sometimes it's difficult to figure out everyone who's involved when some kids are running to the fight and some are running away."
The disturbances, which reportedly began in the gymnasium, threw off the regular bell schedule and a modified lunch and class schedule was established for the remainder of the day.
"We will be issuing the appropriate punishments based on our handbook," said Edwards."
He added that the Drew-Ruleville rivalry has not been as big of an issue as many in the communities anticipated, and for the most part, Drew students are performing very well in academics and athletics.
"We're seeing that many of the Drew students are achieving as high or higher than Ruleville students," he said. "They've done a great job with the transition."