The annual Sales Tax Holiday begins at 12:01 a.m. July 26, and ends midnight July 27.
Parents often make use of the holiday to stock up on clothing before children return for a new school year.
Sharva Mabry, co-manager of Cleveland's Walmart, said she expects a busy turnout at the store, especially from local families.
"We're hoping for a large crowd," said Mabry. "We know it's going to be really busy in our apparel section. We're looking forward to everyone coming out to shop.
"And even though school supplies are not tax exempt, we always make sure to have these items stocked and ready during the holiday."
Abraham's Men's Shoppe owner Danny Abraham said the weekend is consistently a busy one.
"It's a great boost for local businesses and the economy," said Abraham. "Thank God our state leaders understand the significance of it.
"We always bring in extra staff that weekend to accommodate the extra shoppers."
Haley Huerta, owner of H Squared Boutique in downtown Cleveland is also gearing up for the affair.
"We expect a lot of customers to take advantage of Sales Tax Holiday," said Huerta. "It's the perfect time of year to come out and purchase your back-to-school apparel and fall outfits."
The items exempt from sales tax during the holiday are identical to those items exempt in prior years.
Miss. Code Ann. Section 27-65-111(bb) provides the tax break statewide to all consumer purchases of clothing and footwear less than $100.00 per article.
Shoppers should take notice of items eligible for the weekend, as defined in a statement by The Mississippi Department of Revenue.
Clothing is outlined as any article of apparel designed to be worn on the human body including pants, shirts and blouses, dresses, coats, jackets, belts, hats, undergarments and multiple piece garments sold as a set.
Footwear includes any article of apparel for human feet except for skis, swim fins, roller blades, skates and any similar items. Cleats and items worn in conjunction with an athletic or recreational activity are not eligible.
Accessories such as jewelry, handbags, luggage, umbrellas, wallets, watches, backpacks, briefcases and similar items do not qualify.
School supplies and computers are not exempt.
Exempt items are not limited to youth products, and many adults also take advantage of the break.
Mississippi has several special conditions to follow: layaways are not tax exempt; only store coupons and discounts can be used to lower the price below the dollar limit; manufacturer's coupons can't be used to bring the price below the threshold; and rain check purchases are only exempt if the item is bought during the sales tax holiday.
The following municipalities are suspending Sales Tax Holiday within their corporate limits and will not participate this year: Crenshaw, Enterprise, and Heidelberg.
All retail businesses within the corporate limits of the municipality not participating must charge and remit to the state sales tax on all sales that would normally be exempt under the event.
For more information, visit www.dor.ms.gov/secondsalestaxholiday.html.